Is is possible for a female cat to mate with a skunk?

I ume your joking about the part skunk part, since he is not 1/2 skunk it's not possible they are two different species. He is just spraying urine, something mainly male cats and sometimes females will do. Even fixed males will still spray. Our fixed male got scared once and did a little spray of urine while running away, but he has never done it again. So it's something that any cat breed can do.